344

24

The Nervous System

24.4

Neurocomputation

Microelectrodes have long been used to investigate brain tissues. 10 Following

the famous demonstration of the interfacing of living neurons with conventional

semiconductor-based electronic circuits, 11 it was hoped that vast computing power

could be unleashed by artificial networks of living neurons, artificial in the sense that

their connexions would be specified by a human circuit designer. 12 Despite progress,

the trend in neural computation is to work with mathematical models run on com-

puters, with practical interest in such areas as natural language processing, image

recognition, robotics and healthcare. Significant developments in deep learning are

convolutional neural networks (CNNs) and recurrent neural networks (RNNs). CNNs

are specifically designed to process data represented by a grid-like structure (e.g.,

images). Features are extracted using a series of filters, and the features are then

used to detect or classify objects in the image. In contrast, RNNs are designed for

processing sequential data, such as time series (e.g., audio or video), or text.

Problem. Program a general purpose computer to act as a neural network for iden-

tifying objects according to their essential attributes.

References

Adrian ED, Forbes A (1922) The all-or-nothing response of sensory nerve fibres. J Physiol 56:301–

330

Bargmann CI, Marder E (2013) From the connectome to brain function. Nat Methods 10:483–490

Fan X, Markram H (2019) A brief history of simulation neuroscience. Frontiers Neuroinformatics

13:32

Forró Cs et al (2018) Modular microstructure design to build neuronal networks of defined functional

connectivity. Biosens Bioelectron 122:75–87

Hopfield JJ (1982) Neural networks and physical systems with emergent collective computational

abilities. Proc Natl Acad Sci USA 79:2554–2558

Jánossy V, Tóth A, Bodócs L, Imrik P, Madarász E, Gyévai AT (1990) Multielectrode culture

chamber: a device for long-term recording of bioelectric activities in vitro. Acta Biol Hung

41:309–320

Jánossy V et al (1991) Multichannel recordings and data analysis from spinal cord explants and cell

cultures (Technical Report KFKI-1991-12/H). Central Research Institute for Physics, Hungarian

Academy of Sciences, Budapest

Markin VS, Pastushenko VF, Chizmadzhev YuA (1987) Theory of excitable media. Wiley, New

York

Obien MEJ, Deligkaris K, Bullmann T, Bakkum DJ, Frey U (2015) Revealing neuronal function

through microelectrode array recordings. Front Neurosci 8:423

Panzeri S, Pola G, Petroni F, Young MP, Petersen RS (2002) A critical assessment of different

measures of the information carried by correlated neuronal firing. Biosystems 67:177–185

Ramsden JJ (2001) Computational aspects of consciousness. Psyche Probl Perspect 1:93–100

10 See, e.g., Jánossy et al. (1990); Jánossy et al. (1991); Obien et al. (2015).

11 Zeck and Fromherz (2001).

12 See Suzuki et al. (2004) and Forró Cs et al. (2018) for a flavour of this endeavour.